Seminar
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The title of the talk will be announced soon
Speaker: Theresa Unseld, Institut für Epidemiologie und Medizinische Biometrie, Universität Ulm
Date and Time: 08.05.2023 at 4:15 p.m., TU Dortmund, CDI 120
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Novel clinical trial designs for precision oncology
Speaker: Prof. Dr. Annette Kopp-Schneider, Deutsches Krebsforschungszentrum in der Helmholtz-Gemeinschaft, Heidelberg
Date and Time: 23.01.2023 at 4:15 p.m., TU Dortmund, via Zoom
Abstract: The aim of precision oncology is to provide a targeted therapy for each individual tumor. To reach this goal, it is necessary to identify in each patient actionable biomarkers and to determine a matched targeted therapy for the specific biomarker(s). Clinical trials are necessary to investigate whether the biomarker-treatment combination in fact has the desired effect. Due to the large number of possible biomarker-treatment combinations, and due to the small patient numbers matching such a combination, classical clinical phase III trials are not feasible in this situation. Precision oncology therefore requires the development of novel trials designs. We will discuss the concepts of basket, umbrella and platform designs for precision oncology and will present the challenges for the statistical analysis in these trial designs. Bayesian methods are naturally suited for precision oncology clinical trials as they allow for more flexible designs and they are suited for incorporation of external information and for borrowing of information between arms of clinical trials. We will discuss the use of Bayesian methods for clinical trials and present some current developments.
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Optimal test procedures for multiple hypotheses controlling the familywise expected loss
Speaker: Prof. Dr. Frank Bretz, Novartis Pharma AG, Biostatistics & Statistical Reporting, CH-4002 Basel, Switzerland
Date and Time: 16.01.2023 at 4:15 p.m., TU Dortmund, CDI 120
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Genotoxicity Assessments of Pharmaceuticals
Speaker: Prof. Dr. Helena Geys, Hasselt University, Belgium
Date and Time: 05.12.2022 at 4:15 p.m., TU Dortmund, CDI 120
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A novel group-sequential phase II design for clinical trials with binary endpoints based on Bayesian evidence values
Speaker: Dr. Riko Kelter, Department of Mathematics, Research Group Stochastics, University of Siegen
Date and Time: 28.11.2022 at 4:15 p.m., TU Dortmund, CDI 120
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A replication crisis in methodological statistical research?
Speaker: Prof. Dr. Anne-Laure Boulesteix, Institut für Medizinische Informationsverarbeitung Biometrie und Epidemiologie (IBE), Fakultät der LMU München
Date and Time: 14.11.2022 at 4:15 p.m., via Zoom
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Shinybrms and projpred: Introductory and advanced Bayesian (and not-so-Bayesian) statistics in practice
Speaker: Frank Weber, Institut für Biostatistik und Informatik in Medizin und Alternsforschung (IBIMA)
Universitätsmedizin RostockDate and Time: 07.11.2022 at 4:15 p.m., TU Dortmund, CDI 120
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Virtual Control Groups: Using historical toxicity data to replace control-group animals
Speaker: Alexander Gurjanov, PHD Student at Bayer Pharmaceuticals
Date and Time: 17.10.2022 at 4:15 p.m., TU Dortmund, CDI 120
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Talk 1: An Intro to ToxicR and Bayesian Dose-Response
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Talk 2: Fast Bayesian Gaussian Process Regression Using Compression H-Matrices
Speaker: Matt Wheeler, Ph.D. National Institute of Environmental Health Sciences
Date and Place: 23.09.2022 at 9:30 a.m., TU Dortmund, CDI 116 and via Zoom
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The Hazelwood Health study and other opportunities in Australia
Speaker: Prof. Michael Abramson, School of Public Health & Preventive Medicine, Monash University, Australia
Date and Time: 29.08.2022 at 4:15 p.m. via Zoom
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Random forests on high-dimensional data: from classification and survival analysis to generative modelling
Speaker: Prof. Dr. Marvin N. Wright, Leibniz-Institut für Präventionsforschung und Epidemiologie – BIPS, Bremen
Date and Time: 04.07.2022 at 4:15 p.m., TU Dortmund, M/E 21 and via Zoom
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Issues in supervised prediction and classification for complex chemical substances
Speaker: Prof. Fred Wright, Ph.D., Departments of Statistics and Biological Sciences, North Carolina State University, USA
Date and Time: 27.06.2022 at 4:15 p.m., TU Dortmund, M/E 21 and via Zoom
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Modeling Heterogeneity for Stratified Populations
Speaker: Prof. Menggang Yu, Department of Biostatistics and Medical informatics, University of Wisconsin-Madison, USA
Date and Time: 24.06.2022 at 12:00 p.m., TU Dortmund, M/E 21 and via Zoom
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Propensity Score: an Alternative Method of Analyzing Intervention Effect
Speaker: Prof. Dr. sc. hum. Oliver Kuß, Deutsches Diabetes-Zentrum, Düsseldorf
Date and Time: 20.06.2022 at 4:15 p.m. via Zoom
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Gene expression to Omics: The evolution of genetic research
Speaker: Ashtyn Areal, IUF Düsseldorf
Date and Time: 30.05.2022 at 4:15 p.m. via Zoom
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Analysis and design of clinical trials with biologics using dose-time-response models
Speaker: Markus Lange, Novartis
Date and Time: 23.05.2022 at 4:15 p.m. via Zoom
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The case time series design for high-dimensional data analyses
Speaker: Prof. Antonio Gasparrini, London School of Hygiene and Tropical Medicine, London, UK
Date and Time: 16.05.2022 at 4:15 p.m. via Zoom
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Mehrstadien-Modelle in der Epidemiologie chronischen Erkrankungen
Speaker: Prof. Dr. rer. nat. Ralph Brinks , Lehrstuhl für Medizinische Biometrie und Epidemiologie, Private Universität Witten/Herdecke gGmbH
Date and Time: 09.05.2022 at 4:15 p.m. via Zoom
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Assessing interactive effects of air pollution and temperature– approaches and challenges?
Speaker: Dr. Susanne Breitner , Helmholtz-Zentrum München
Date and Time: 14.02.2022 at 4:15 p.m. via Zoom
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Dose- response analysis in toxicology: considering dose both as qualitative factor and quantitative covariate (using R)
Speaker: Prof. Dr. Ludwig Hothorn, Biostatistician, Retired from Leibniz University Hannover
Date and Time: 24.01.2022 at 4:15 p.m. via Zoom
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Systems genetics strategies for describing the transcriptional connectome and it's role in complex traits
Speaker: Associate Professor Laura Saba, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, USA
Date and Time: 10.01.2022 at 4:15 p.m. via Zoom
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Can statistics save preclinical research?
Speaker: Prof. Dr. med. Ulrich Dirnagl, Abteilungsdirektor Experimentelle Neurologie, Charité Berlin
Date and Time: 06.12.2021 at 4:15 p.m. via Zoom
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Dose-response analysis for gene-expression data
Speaker: Scott S. Auerbach, PhD, und Matt Wheeler, PHD, Institute of Environmental Health Sciences, Durham, NC, USA
Date and Time: 29.11.2021 at 4:15 p.m. via Zoom
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Good Scientific Practise for Doctoral Researchers
Speaker: Dr. Peter Schröder, brain4hire, Graduiertenzentrum TU Dortmund
Date and Time: 15.11.2021 at 4:15 p.m. via Zoom
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Recent extensions on boosting for statistical modelling
Speaker: Prof. Dr. Andreas Mayr, Head of WG Statistical Methods in Epidemiology, Universität Bonn
Date and Time: 25.10.2021 at 4:15 p.m. via Zoom
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Polygenic risk scores – Applicability beyond risk prediction and for different omics data
Speaker: Anke Hüls, PhD, MSc, Assistant Professor, Department of Epidemiology and Gangarosa Department of Environmental Health, Emory University
Date and Time: 05.08.2021 at 4:15 p.m. via Zoom
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Advances in dose-response analysis
Speaker: Prof. Christian Ritz , National Institute of Public Health,Copenhagen
Date and Time: 28.06.2021 at 4:15 p.m. via Zoom
Suche & Personensuche
Anfahrt & Lageplan
Der Campus der Technischen Universität Dortmund liegt in der Nähe des Autobahnkreuzes Dortmund West, wo die Sauerlandlinie A45 den Ruhrschnellweg B1/A40 kreuzt. Die Abfahrt Dortmund-Eichlinghofen auf der A45 führt zum Campus Süd, die Abfahrt Dortmund-Dorstfeld auf der A40 zum Campus-Nord. An beiden Ausfahrten ist die Universität ausgeschildert.
Direkt auf dem Campus Nord befindet sich die S-Bahn-Station „Dortmund Universität“. Von dort fährt die S-Bahn-Linie S1 im 15- oder 30-Minuten-Takt zum Hauptbahnhof Dortmund und in der Gegenrichtung zum Hauptbahnhof Düsseldorf über Bochum, Essen und Duisburg. Außerdem ist die Universität mit den Buslinien 445, 447 und 462 zu erreichen. Eine Fahrplanauskunft findet sich auf der Homepage des Verkehrsverbundes Rhein-Ruhr, außerdem bieten die DSW21 einen interaktiven Liniennetzplan an.
Zu den Wahrzeichen der TU Dortmund gehört die H-Bahn. Linie 1 verkehrt im 10-Minuten-Takt zwischen Dortmund Eichlinghofen und dem Technologiezentrum über Campus Süd und Dortmund Universität S, Linie 2 pendelt im 5-Minuten-Takt zwischen Campus Nord und Campus Süd. Diese Strecke legt sie in zwei Minuten zurück.
Vom Flughafen Dortmund aus gelangt man mit dem AirportExpress innerhalb von gut 20 Minuten zum Dortmunder Hauptbahnhof und von dort mit der S-Bahn zur Universität. Ein größeres Angebot an internationalen Flugverbindungen bietet der etwa 60 Kilometer entfernte Flughafen Düsseldorf, der direkt mit der S-Bahn vom Bahnhof der Universität zu erreichen ist.
Interaktive Karte
Die Einrichtungen der Technischen Universität Dortmund verteilen sich auf den größeren Campus Nord und den kleineren Campus Süd. Zudem befinden sich einige Bereiche der Hochschule im angrenzenden Technologiepark.
Zum Lageplan